FIG. 5.

Model for preferential translation of newly appearing mRNAs during VSV infection. (A and B) Modification of translation machinery during VSV infection, indicated by dephosphorylation of eIF4E (A), leads to inhibition of translation of preexisting host mRNAs (B). (C) Reinitiation of translation is prevented by shuttling of these mRNAs into translationally inactive mRNPs. (D) Viral transcription provides a continuous supply of newly synthesized viral mRNAs, which are translated by the reprogrammed translation apparatus. (E) M protein enhances translation of viral mRNAs.