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Association of ICP4 and polII with the ICP0 and tk promoters in n12- and KOS-infected cells. ChIP experiments were performed as described in Materials and Methods. The graphs give the number of genomes bound by the tk and ICP0 promoters on the n12 and KOS genomes to ICP4 and polII. In this experiment we compare wt (KOS) to the ICP4 mutant n12 at 4 and 8 h postinfection.
