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Schema of treatment and immunizations. Ten woodchucks with chronic WHV infection were divided into three groups. For 21 weeks, 15 mg of lamivudine was given orally to all woodchucks. The first group (n = 2) served as the control and did not receive any vaccinations. The second group (n = 4) was immunized with the combination of three plasmids expressing WHsAg, WHcAg, and woodchuck gamma interferon. The third group (n = 4) received three immunizations with WHsAg-IC and plasmid pWHsIm.
