FIG. 3.

Detailed views of the modified rNV VLP atomic model. (A) Stereo representation of the cross section of the rNV VLP structure as modified to fit into the MNV structure. The orientation shown here differs from that in Fig. 1 in order to demonstrate the new and extensive interactions (denoted by the line marked A) between the P1 domains (red and green P1 interactions). (B) For clarity, this is a slightly expanded view of panel A with only the ribbon diagram displayed. In this view, the new and extensive interactions between the B and C subunits (green and red, respectively) are clearly visible. (C) Stereo view of the ribbon diagrams of the rNV P domains as assembled in the rNV particle. The view here is into the icosahedral twofold axes. Note that there are relatively few interactions among the P domains and that the side protrusion of the P1 domain (denoted by A) points into the space between the P domains. Also note that the spaces at the fivefold and quasi-sixfold (Q6) axes are significantly smaller than MNV in the panel below. (D) Stereo view of MNV in the same orientation. Note that the P1 domain protrusions (denoted by the letter A) now interact at the quasi-threefold axes as also shown in panel B. The lifting and rotation of the P domains open the gaps at the fivefold and quasi-sixfold (icosahedral threefold) axes.