TABLE 3.
Replication of challenge viruses in immunized mice at day 3 postchallenge
| Challenge virus | Group | Virus titer (mean log10 PFU/g ± SD) ina:
|
||||
|---|---|---|---|---|---|---|
| Lungs | Nasal turbinates | Brains | Spleens | Kidneys | ||
| VN1203 | PBS | 7.83 ± 0.46 | 6.11, 4.19 | 3.04 | 4.96 ± 0.66 | 2.78, 4.27 |
| M2del11-HAavir | ||||||
| 100 PFU | NDb | ND | ND | ND | ND | |
| 1,000 PFU | ND | ND | ND | ND | ND | |
| Indonesia 7 | PBS | 9.06 ± 0.10 | 7.01 ± 0.21 | 3.32 ± 1.37 | 5.64 ± 0.12 | 4.27 ± 0.38 |
| M2del11-HAavir | ||||||
| 100 PFU | N D | ND | ND | ND | ND | |
| 1,000 PFU | ND | 1.96 | ND | ND | ND | |
a
Three mice from each group were sacrificed on day 3 postchallenge for virus titration. When virus was not recovered from all three mice, individual titers were recorded.
b
ND, not detected.