FIG. 3.

NKG2D neutralization in JHMV-infected SCID mice does not affect survival. (A) Quantitative real-time PCR of brain mRNA demonstrated that levels of transcripts for NKG2D ligands are increased in SCID mice compared to those of sham-infected mice at days 3 and 5 p.i. (B) Treatment of SCID mice with anti-NKG2D did not affect host survival compared to that of mice treated with control antibody. Data are presented as averages from two independent experiments with no fewer than six mice per group. (C) Levels of viral recovery from the brains of mice treated with anti-NKG2D or rat IgG were equivalent at all time points assayed. The viral burden is presented from a representative experiment of two independent experiments with three mice per group per time point. Circles represent individual mice, while bars represent the averages of the treatment group.