TABLE 4.

p53 sequence analysis for cancerous prostate specimens

Specimen	Localizationa of:		p53 sequenceb
	TAg	p53	Exon	Entire thin section	LCM cellsc
C1	Cyto	Cyto	5-6	wt, mt (Thr 140 to Ile)	wt
			9	wt	ND
C2	Cyto	Cyto	5-6	wt	wt
			7-8	wt	wt
			9	wt	wt
C3	Cyto	Cyto	5-6	wt	wt
			7-8	wt	wt*
			9	wt	wt
C4	Cyto	Cyto	5-6	mt (Pro 191 to Leu)	wt
			7-8	wt	wt
			9	wt	wt
C5	Cyto	Cyto	5-6	ND	wt
			7-8	wt	wt*
			9	wt	wt
C6		Nuc	5-6	wt	wt
			7-8	wt	wt
			9	wt	wt, mt (Pro 318 to Ser)
C7		Nuc	5-6	wt	wt
			7-8	wt	wt*
			9	wt	wt
C8		Nuc	5-6	wt	wt
			7-8	wt	wt*
			9	ND	wt

^aNuc, nuclear; Cyto, cytoplasmic.

^bwt, wild type; mt, mutant; ND, not determined.

^cLCM was performed on TAg⁺ PIA cells (specimens C1 to C5) and on Tag⁻ tumor cells (specimens C6 to C8). Asterisks indicate specimens for which the exon 8 sequence could be amplified but good-quality sequence could not be obtained.