Table II.
Summary of inhibitory activity (IC50a) of KTIs against different proteases
| KTI | Trypsin | Chymotrypsin | Elastase | Subtilisin | Papain |
|---|---|---|---|---|---|
| μm | |||||
| TI2 | 0.0280 | 2.95 | NA | NA | NA |
| TI3 | 0.152 | 0.152 | 74.1 | NA | NA |
| TI4 | 128 | 0.294 | NA | NA | NA |
| TI5 | 0.205 | 0.188 | 9.16 | NA | NA |
| TI6 | 0.643 | 0.111 | 0.731 | NA | NA |
| GmKTI | 0.0116 | 0.0567 | 3.65 | NA | NA |
ICs were calculated from the linear portion of the plot of residual proteinase activity against TI protein concentration (Fig. 7). NA, No activity.