Table 3. Grade 3–4 haematological toxicity and management in both arms.
CIP (n=101) | CEP (n=98) | ||
---|---|---|---|
Toxicity | % | % | P |
Anaemia | 48 | 27 | 0.002 |
Leukopaenia | 95 | 76 | 0.0001 |
Neutropaenia | 97 | 95 | 0.51 |
Thrombocytopaenia | 37 | 25 | 0.08 |
Febrile neutropaenia, grade 3 | 14 | 3 | 0.007 |
G-CSF | 48 | 22 | 0.0002 |
Transfusion | 37 | 22 | 0.03 |
Hospitalisation | 34 | 19 | 0.02 |
Abbreviations: CEP=cisplatin/paclitaxel/epirubicin; CIP=cisplatin/paclitaxel/ifosfamide; G-CSF=granulocyte colony-stimulating factors.