Table 4. Grade 3–4 toxicities.
|
IP (n=54)
|
IPE (n=55)
|
|||||
|---|---|---|---|---|---|---|
| Grade 3 | 4 | 3+4 (%) | Grade 3 | 4 | 3+4 (%) | |
| Leukocytopaenia | 9 | 1 | 10 (19) | 18 | 11 | 29 (53)* |
| Neutropaenia | 17 | 11 | 28 (52) | 24 | 28 | 52 (95)* |
| Anaemia | 18 | 0 | 18 (25) | 16 | 9 | 25 (45) |
| Thrombocytopaenia | 2 | 0 | 2 (4) | 13 | 0 | 13 (13)† |
| Febrile neutropaenia | 5 | 0 | 5 (9) | 17 | 0 | 7 (13) |
| Diarrhoea | 8 | 0 | 8 (15) | 11 | 2 | 13 (24) |
| Vomiting | 4 | 0 | 4 (7) | 3 | 0 | 3 (5) |
| Fatigue | 1 | 0 | 1 (2) | 5 | 1 | 6 (11)‡ |
| Hyponatraemia | 9 | 3 | 12 (22) | 11 | 2 | 13 (24) |
| AST elevation | 0 | 0 | 0 (0) | 3 | 0 | 3 (5) |
| CRN elevation | 1 | 0 | 1 (2) | 0 | 0 | 0 (0) |
*P<0.001; †P<0.01; and ‡P=0.054 by χ2 test.