Table 6. Univariate and multivariate analyses of prognostic factors for locoregional recurrence-free survival for patients treated by breast conservation.

			Univariate analysis		Multivariate analysisa
	N	10-year LRRFS (%)(IC 95%)	P b	RR (IC 95%)	P c	RR (IC 95%)
Age (continuous variable)			0.0009	0.96 (0.94–0.98)
Age (dummy variable) d			<10−6		<10−5
>40	382	77 (72–82)		1		1
⩽40	94	49 (38–63)		2.6 (1.8–3.7)		2.6 (1.7–3.7)
Menopause d			0.1
No	353	69 (63–74)		1
Yes	123	80 (73–88)		0.7 (0.4–1.1)
Clinical tumour stage d			0.81
cT2	391	72 (67–77)		1
cT3	85	71 (60–83)		1.1 (0.7–1.7)
Clinical nodal status d			0.06
cN0	315	73 (68–79)		1
cN1	161	68 (60–77)		1.4 (1.0–2.1)
Histological type d			0.12
Ductal	434	72 (68–77)		1
Lobular	42	62 (47–82)		1.5 (0.9–2.6)
Hormonal receptors d			0.54
HR+	291	72 (66–78)		1
HR−	114	68 (59–79)		1.1 (0.7–1.7)
Histological grade			0.97
Grade 1	71	73 (63–85)		1
Grade 2	215	70 (63–77)		1.0 (0.6–1.6)
Grade 3	156	72 (64–81)		0.9 (0.5–1.6)
Mitotic index			0.72
Grade 1	110	71 (62–83)		1
Grade 2	125	72 (64–82)		1.1 (0.7–1.8)
Grade 3	195	70 (63–78)		1.2 (0.8–1.9)
Clinical response			0.29
⩾50%	343	74 (69–79)		1
<50%	127	67 (58–77)		1.2 (0.8–1.8)
Locoregional treatment			<10−3
Postop	308	77 (71–83)
Preop/excl	168	61 (53–70)		2.0 (1.4–2.8)

HR=hormonal receptor; LRRFS=locoregional recurrence-free survival

^aMultivariate analysis after stratification on local treatment.

^bLog-rank test.

^cLikelihood ratio test.

^dFactors entered in the multivariate analysis.

Preop/excl: locoregional treatment consisted in preoperative or exclusive radiotherapy.