Table 7. Univariate and multivariate analyses of prognostic factors for overall survival.

			Univariate analysis		Multivariate analysis
	N	10-year LRRFS (%)(IC 95%)	P	RR (IC 95%)	P	RR (IC 95%)
Age (continuous variable)			0.7	1.0 (0.99–1.02)
Age (dummy variable)			0.11
>40	597	67 (63–72)		1
⩽40	153	60 (52–69)		1.3 (0.9–1.7)
Menopause a			0.22
No	563	67 (63–72)		1
Yes	187	63 (55–71)		1.2 (0.9–1.6)
Clinical tumour stage a			0.005
cT2	556	68 (64–73)		1
cT3	194	59 (51–67)		1.5 (1.1–1.9)
Clinical nodal status a			<10−7		<10−3
cN0	465	73 (69–78)		1		1
cN1	285	54 (48–61)		2.0 (1.6–2.6)		2.1 (1.6–2.7)
Histological type			0.44
Ductal	672	65 (61–69)		1
Lobular	78	72 (62–84)		0.8 (0.6–1.3)
Hormonal receptors (HR) a			<10−7		<10−3
HR+	466	70 (66–75)		1		1
HR−	166	49 (42–58)		2.2 (1.7–2.8)		2.4 (1.8–3.2)
Histological grade a , b			0.0004		0.02
Grade 1	114	78 (69–87)		1		1
Grade 2	362	66 (61–71)		1.8 (1.1–2.8)		1.8 (1.1–2.8)
Grade 3	217	58 (51–66)		2.5 (1.6–3.9)		1.9 (1.2–3.1)
Mitotic index a			<10−4
Grade 1	182	77 (70–85)		1
Grade 2	189	67 (60–74)		1.6 (1.1–2.4)
Grade 3	297	59 (53–65)		2.2 (1.5–3.2)
Clinical response a			0.15		0.003
⩾50%	434	67 (63–73)		1		1
<50%	309	64 (58–70)		1.2 (0.9–1.6)		1.5 (1.2–2.0)

HR=hormonal receptor; LRRFS=locoregional recurrence-free survival

^aFactors entered in the multivariate analysis.

^bThe mitotic index was not entered into the model as it was highly correlated with the histological grade.