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Potentiation of the effects of (−)-adrenaline by rolipram but not by cilostamide on left atrium. Representative experiments, depicting cumulative concentration–effect curves for (−)-adrenaline in the absence of PDE inhibitors (a), in the presence of rolipram (b) and in the presence of cilostamide (c). Black spots indicate −log(−)-adrenaline concentrations, achieved by cumulative administration. Ca, CaCl2 (9 mM); Iso, (−)-isoprenaline (200 μM).
