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Effect of isoprenaline on beat duration. (a) Time-to-peak contraction (TTP), time from peak to 50% relaxation (R50), time from peak to 90% relaxation (R90) in hESC-CM from nine experiments before (basal) and after (Iso) exposure to 10 μM isoprenaline (**P<0.01, ***P<0.001 vs basal). (b) Example trace of the contraction before and during exposure to isoprenaline. hESC-CMs, human embryonic stem cell-derived cardiomyocytes.
