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Heterogeneity of microtumor growth from single cells. H35 rat hepatoma cells proliferated into multicellular “microtumors.” One of the fastest (a–d) and slowest(e–h) growing microtumors at 0, 4, 10, and 12 days. Growth was quantified based on area and is presented at right for the fastest (open circles) and slowest (closed triangles) growing cells, as well as the mean of 18 microtumors with standard deviation (closed circles)
