Table 2.

Structural, numerical, and total chromosome aberrations in cultured human lymphocytes treated with BA⁺

Test substance	Treatment		Structural CA			Numerical CA ± SE (%) (P+E)*	Total CA ± SE (%)
	Periods (h)	Concentration (μg/mL)	Chromatid	Chromosome type	Total ± SE (%)
Control	–	–	9	7	4.00 ± 0.91	–	4.00 ± 0.91
DMSO	24	10 μL/mL	11	8	4.75 ± 0.62	–	4.75 ± 0.62
MMC	24	0.25	50	56	31.00 ± 0.40	–	31.00 ± 0.40
BA	24	400	19	10	7.25 ± 0.94 a1	0.25 ± 0.25	7.50 ± 0.86 a1b1
		600	22	13	8.75 ± 0.75 a2b1	–	8.75 ± 0.75 a2b1
		800	27	17	11.00 ± 1.68 a1b1	–	11.00 ± 1.68 a1b1
		1000	22	24	11.50 ± 0.86 a2b2	0.50 ± 0.28	12.00 ± 0.57 a3b3
DMSO	48	10 μL/mL	5	22	6.75 ± 0.47	–	6.75 ± 0.47
MMC	48	0.25	150	116	66.25 ± 1.84	–	66.25 ± 1.84
BA	48	400	29	22	13.50 ± 1.75 a1b1	0.50 ± 0.28	14.00 ± 1.47 a2b1
		600**	22	11	11.33 ± 1.85a1	–	11.33 ± 1.85 a1
		800**	37	17	23.00 ± 3.67 a1b1	–	23.00 ± 3.67 a1b1
		1000***	20	13	29.00 ± 4.50 a1b1	–	29.00 ± 4.50 a1b1

⁺ A total of 400 cells were scored

* P, polyploid; E, endoreduplication

** Only 270 cells and *** 150 cells were scored due to excessive toxicity

a, significant difference from control; b, significant difference from solvent (DMSO) control

a₁b₁: p < 0.05; a₂b₂: p < 0.01; a₃b₃: p < 0.001