Table 2.
Drug | Nominal (ng/mL) | GM (ng/mL) | SD (ng/mL) | DEV (%) | BRP (%) | WRP (%) | n |
---|---|---|---|---|---|---|---|
ABI-007 | 30 | 31.8 | 2.8 | 6.0% | 8.1% | 4.5% | 19 |
ABI-007 | 150 | 159.1 | 8.4 | 6.1% | 2.0% | 5.0% | 20 |
ABI-007 | 2,000 | 1,893.7 | 122.7 | −5.3% | 5.6% | 4.2% | 20 |
ABI-007 | 25,000 | 24,709.9 | 2,557.1 | −1.2% | 10.4% | 4.1% | 19 |
Paclitaxel | 150 | 149.2 | 6.5 | −0.5% | 3.5% | 2.9% | 19 |
Unbound ABI-007 | 2,000 | 99.8 | 10.0 | n/a | 9.64% | 5.14% | 20 |
Abbreviations: GM, grand mean; SD, standard deviation; DEV, percent deviation from nominal value; BRP, between run precision; WRP, within run precision; n, total number of replicate observations within the validation runs.
Four or five samples at each concentration were analyzed on four different occasions.