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. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: Dev Biol. 2007 Sep 20;312(1):183–192. doi: 10.1016/j.ydbio.2007.09.017

Table 1.

CFTR-inhibitor 172 does not prevent acceleration of the beat by NaHCO3

Medium Beat Frequency (Hz)
(Mean ± SEM)
HS 2.33 ± 0.23a,c
HS + 15 mM NaHCO3 6.70 ± 0.32b,c
HS + 10 μM CFTR-i172 2.84 ± 0.15a,d
HS + 10 μM CFTR-i172 + 15 mM NaHCO3 6.25 ± 0.30b.d
a

Not significantly different (P>0.15, paired t-test)

b

Not significantly different (P>0.35, paired t-test)

c,d

Significantly different (P<0.001, paired t-test)

Sperm were bathed for 5-10 min with medium HS in the presence or absence of 10 μM CFTR-i172. Representative sperm were selected for waveform analysis then perfused for 1 min with the same medium supplemented with 15 mm NaHCO3 and resampled.

N= 20 cells for each group in 2 independent experiments