Table 2.

Kinetic parameters. Concentrations and the Michaelis-Menten constants (K₄, K₈, and K₁₁-K₁₉) are given in [nM]. First- and second-order rate constants are given in [s^-1] and [nM^-1·s^-1], respectively. V₄, V₈, and V₁₁-V₁₉ are expressed in [nM·s^-1].

Reaction number	Equation	Kinetic parameter		Reference
v1	k1·X1·X2 - k-1·X3	k1 = 0.003	k-1 = 0.06	[11]
v2	k2·X3·X3 - k-2·X4	k2 = 0.01	k-2 = 0.1	[11]
v3	k3·X4 - k-3·X5	k3 = 1	k-3 = 0.01	[11]
v4	V4·X5/(K4 + X5)	V4 = 450	K4 = 50	[11]
v5	k5·X5·X6 - k-5·X7	k5 = 0.06	k-5 = 0.2	[11]
v6	k6·X7 - k-6·X8	k6 = 1	k-6 = 0.05	[11]
v7	k7·X8 - k-7·X5·X9	k7 = 0.3	k-7 = 0.006	[11]
v8	V8·X9/(K8 + X9)	V8 = 1	K8 = 100	[11]
v9	k9·X9 - k-9·X10	k9 = 1	k-9 = 0.03	[11]
v10	k10·X9·X11 - k-10·X12	k10 = 0.214	k-10 = 5.25	Estimate
v11	V11·X12·X13/(K11 + X13)	V11 = 4	K11 = 64	[39]
v12	V12·X14·X15/[K12·(1 + X16/K14) + X15]	V12 = 3.5	K12 = 317	[14]
v13	V13·X16/[K13·(1 + X17/K15) + X16]	V13 = 0.058	K13 = 2200	[12]
v14	V14·X14·X16/[K14·(1 + X15/K12) + X16]	V14 = 2.9	K14 = 317	[12]
v15	V15·X17/[K15·(1 + X16/K13) + X17]	V15 = 0.058	K15 = 60	[12]
v16	V16·X17·X18/[K16·(1 + X19/K18) + X18]	V16 = 9.5	K16 = 1.46 × 105	[12]
v17	V17·X19/[K17·(1 + X20/K19) + X19]	V17 = 0.3	K17 = 160	[12]
v18	V18·X17·X19/[K18·(1 + X18/K16) + X19]	V18 = 16	K18 = 1.46 × 105	[12]
v19	V19·X20/[K19·(1 + X19/K17) + X20]	V19 = 0.27	K19 = 60	[12]