Table 2.
Downregulated genes in primary pancreatic tumors. Relative fold change in primary pancreatic tumors compared to normal pancreas (PT/NP) and in liver metastatic lesions compared to primary pancreatic tumors (LM/PT)
| Entrez Gene# | Fold change LM/PT | Fold change PT/NP | Gene Symbol | Gene description | Ref.* |
| Cell adhesion, motility and migration | |||||
| 12340 | 0.84 | -11.6 | Capza1 | Capping protein (actin filament) muscle Z-line, alpha 1 | 16 |
| 12829 | 0.98 | -10.8 | Col4a4 | Procollagen, type IV, alpha 4 | |
| 13643 | 1.02 | -7.6 | Efnb3 | Ephrin B3 | |
| 215384 | 1.03 | -8 | Fcgbp | Fc fragment of IgG binding protein | |
| 16855 | 1.00 | -6.4 | Lgals4 | Lectin, galactose binding, soluble 4 | |
| 17831 | 1.02 | -40 | Muc2 | Mucin 2 | |
| 219228 | 1.51 | -18.8 | Pcdh17 | Protocadherin 17 | |
| 68799 | 1.20 | -7.2 | Rgmb | RGM domain family, member B | |
| 16855 | 1.00 | -6.4 | Lgals4 | Lectin, galactose binding, soluble 4 | |
| Cell communication and signal trasduction | |||||
| 12154 | 1.09 | -4 | Bmp10 | Bone morphogenetic protein 10 | |
| 13643 | 1.02 | -7.6 | Efnb3 | Ephrin B3 | |
| 14463 | 1.01 | -8 | Gata4 | GATA binding protein 4 | |
| 15874 | 0.96 | -40 | Iapp | Islet amyloid polypeptide | |
| 16333 | 0.85 | -23.2 | Ins1 | Insulin I | |
| 14526 | 0.91 | -21.6 | Gcg | Glucagon | |
| 70497 | 0.86 | -8 | Arhgap17 | Rho GTPase activating protein 17 | |
| 232201 | 0.83 | -7.6 | Arhgap25 | Rho GTPase activating protein 25 | |
| 110052 | 1.00 | -8.4 | Dek | DEK oncogene (DNA binding) | 16 |
| 14915 | 0.98 | -13.6 | Guca2a | Guanylate cyclase activator 2a (guanylin) | |
| 212307 | 0.81 | -7.2 | Mapre2 | Microtubule-associated protein, RP/EB family, member 2 | |
| 20844 | 1.15 | -13.6 | Stam | Signal transducing adaptor molecule | |
| 66042 | 0.85 | -14.8 | Sostdc1 | Sclerostin domain containing 1 | |
| 68799 | 1.20 | -7.2 | Rgmb | RGM domain family, member B | |
| 80718 | 0.91 | -6.4 | Rab27b | RAB27b, member RAS oncogene family | |
| 18386 | 0.93 | -6 | Oprd1 | Opioid receptor, delta 1 | |
| 67709 | 0.88 | -13.6 | Reg4 | Regenerating islet-derived family, member 4 | |
| Cell cycle and cell proliferation | |||||
| 76499 | 1.02 | -8.8 | Clasp2 | CLIP associating protein 2 | |
| 16333 | 0.85 | -23.2 | Ins1 | Insulin I | |
| 16334 | 0.98 | -40 | Ins2 | Insulin II | |
| 212307 | 0.81 | -7.2 | Mapre2 | Microtubule-associated protein, RP/EB family, member 2 | |
| 22268 | 0.90 | -6 | Upk1b | Uroplakin 1B | |
| 14526 | 0.91 | -21.6 | Gcg | Glucagon | |
| 212307 | 0.81 | -7.2 | Mapre2 | Microtubule-associated protein, RP/EB family, member 2 | |
| 57263 | 1.11 | -28 | Retnlb | Resistin like beta | |
| 12154 | 1.09 | -4 | Bmp10 | Bone morphogenetic protein 10 | |
| 17831 | 1.02 | -40 | Muc2 | Mucin 2 | 19 |
| 17063 | 0.91 | -60 | Muc13 | Mucin 13, epithelial transmembrane | |
| Transporter and binding activity | |||||
| 11773 | 1.09 | -14.8 | Ap2m1 | Adaptor protein complex AP-2, mu1 | |
| 80718 | 0.91 | -6.4 | Rab27b | RAB27b, member RAS oncogene family | |
| 56185 | 1.00 | -19.2 | Hao3 | Hydroxyacid oxidase (glycolate oxidase) 3 | |
| 110052 | 1.00 | -8.4 | Dek | DEK oncogene (DNA binding) | 16 |
| 12829 | 0.98 | -10.8 | Col4a4 | Procollagen, type IV, alpha 4 | |
| 16467 | 1.13 | -11.6 | Atcay | Ataxia, cerebellar, Cayman type homolog (human) | |
| 13487 | 0.95 | -20 | Slc26a3 | Solute carrier family 26, member 3 | |
| 216156 | 0.92 | -4 | Wdr18 | WD repeat domain 18 | |
| 69008 | 1.23 | -6.4 | Cab39l | Calcium binding protein 39-like | |
| 12351 | 0.84 | -4 | Car4 | Carbonic anhydrase 4 | |
| 72832 | 0.93 | -14.8 | Crtac1 | Cartilage acidic protein 1 | |
| 75600 | 1.20 | -8 | Calml4 | Calmodulin-like 4 | |
| Apoptosis | |||||
| 15874 | 0.96 | -40 | Iapp | Islet amyloid polypeptide | |
| 17831 | 1.02 | -40 | Muc2 | Mucin 2 | 19 |
| 71361 | 1.15 | -8 | Amid | Apoptosis-inducing factor, mitochondrion-associated 2 | |
| 16334 | 0.98 | -40 | Ins2 | Insulin II | |
| 17063 | 0.91 | -60 | Muc13 | Mucin 13, epithelial transmembrane | |
| Transcription activity | |||||
| 109275 | 0.94 | -4 | Actr5 | ARP5 actin-related protein 5 homolog (yeast) | |
| 71458 | 0.89 | -6 | Bcor | Bcl6 interacting corepressor | |
| 14463 | 1.01 | Gata4 | GATA binding protein 4 | ||
| Epigenetic and chromatin modification | |||||
| 213742 | 1.00 | -8.8 | Xist | Inactive X specific transcripts | |
| 75796 | 0.86 | -4 | Cdyl2 | Chromodomain protein, Y chromosome-like 2 | |
| Inflammatory and immune response | |||||
| 21786 | 0.90 | -10.8 | Tff3 | Trefoil factor 3, intestinal | |
| 15101 | 0.90 | -7.6 | H60 | Histocompatibility 60 | |
| 94071 | 1.00 | -4 | Clec2h | C-type lectin domain family 2, member h | |
| Cell differentiation | |||||
| 12154 | 1.09 | -4 | Bmp10 | Bone morphogenetic protein 10 | |
| 14463 | 1.01 | -8 | Gata4 | GATA binding protein 4 | |
| 72324 | 0.86 | -4 | Plxdc1 | Plexin domain containing 1 | |
| 20755 | 1.31 | -16 | Sprr2a | Small proline-rich protein 2A | |
| 22268 | 0.90 | -6 | Upk1b | Uroplakin 1B | |
| 75770 | 0.85 | -8.4 | Brsk2 | BR serine/threonine kinase 2 | |
| Maintenance of cell polarity and shape | |||||
| 76499 | 1.02 | -8.8 | Clasp2 | CLIP associating protein 2 | |
| 20755 | 1.31 | -16 | Sprr2a | Small proline-rich protein 2A | |
Ref.* = References identifying genes previously shown to have deregulated expression in pancreatic cancer