Table 4.
Altered proteins in AD
| Protein | Change | Reference |
|---|---|---|
| Heat Shock Proteins | ||
| Alpha crystallin B chain | I | 103;218 |
| Glucose regulated protein 75 kDa (GRP75) | D | 103;218 |
| Glucose regulated protein 75 kDa (GRP94) | I | 103;218 |
| Heat shock 60 kDa, mitochondrial | D | 219 |
| Heat shock 90kDa protein 1, beta | Enriched in amyloid plaques | 99 |
| Heat shock cognate 71 | Oxidation | 104 |
| Heat shock protein 70 RY | I | 103;218 |
| T-complex protein 1 (TCP-1) | D | 220 |
| Synaptosomal proteins | ||
| Beta-soluble N-ethylmaleimide-sensitive factor attachment protein (Beta SNAP) | D | 107 |
| Synaptosomal associated protein 25 kDa (Snap-25) | D | 100 |
| Synaptotagmin I | D | 107 |
| Guidance Proteins | ||
| Didyropyrimidinase-related protein 2 (DRP-2) | D | 108 |
| Signal Transduction Proteins | ||
| 14-3-3 beta/alpha | Enriched in amyloid plaques | 99 |
| 14-3-3 epsilon protein | I | 89;113 |
| 14-3-3 gamma protein | I | 89;113 |
| 14-3-3 zeta | Enriched in amyloid plaques | 99 |
| 2′-3′-Cyclic nucleotide 3-phosphodiesterase (CNPase) | D | 110 |
| Alpha-Endosulfine | D | 221 |
| ARPP-19 | D | 222 |
| cAMP-dependent protein kinase (PKA) | D | 222 |
| Fatty acid-binding protein, heart | D | 219 |
| Guanine nucleotide-binding protein beta subunit | D | 219 |
| Histamin-releasing factor | D | 223 |
| Nucleoside diphosphate kinase A (NDKA) | D | 111 |
| Stathmin | D | 112 |
| Antioxidant proteins | ||
| Alcohol dehydrogenase (ADH) | I | 117 |
| Antioxidant protein 2 (1-Cys peroxiredoxin) (1-Cys Prx) | I | 224 |
| Carbonyl reductase (CBR) | I | 117 |
| Peroxiredoxin I (Prx-I) | I | 118 |
| Peroxiredoxin II(Prx-II) | I | 118;119 |
| Peroxiredoxin III (Prx-III) | D | 119 |
| Peroxiredoxin VI | I | 119 |
| Superoxide dismutase | D | 116 |
| Oxidized Proteins | ||
| Alpha-enolase | Oxidation/Nitration | 104 |
| Beta-actin | Oxidation/D/Nitration | 122;123 |
| Creatine kinase BB | Oxidation/D | 105;225 |
| Didyropyrimidinase-related protein 2 | Oxidation/D | 104 |
| Gamma-Enolase | Oxidation/Nitration | 104 |
| Glutamate Transporter, EAAT2 | Oxidation/D | 123 |
| Glutamine synthase | Oxidation/D | 105 |
| Heat shock cognate 71 | Oxidation | 104 |
| L-Lactate dehydrogenase | Oxidation/Nitration | 104 |
| Neuropolypeptide h3 | Oxidation/Nitration | 104;123;226 |
| Triosephosphate Isomerase | Oxidation/Nitration | 122;226 |
| Ubiquitin carboxy-terminal hydrolase L-1 | Oxidation | 105 |
| Metabolism, Memory | ||
| ATP synthase alpha chain, mitochondrial | D | 219 |
| ATP synthase beta chain, mitochondrial | I | 219 |
| Beta-enolase | D | 219 |
| NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial [Precursor] | D | 227 |
| NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [Precursor] | D | 227 |
| Phosphofructokinase, muscle ttype | Enriched in amyloid plaques | 99 |
| Phosphofructokinase, platelet type | Enriched in amyloid plaques | 99 |
| Ubiquinol-cytochrome-c reductase complex III core protein I | D | 228 |
| Voltage-dependent anion-selective channel protein 1 (VDAC1) | D | 229 |
| Voltage-dependent anion-selective channel protein 2 (VDAC2) | I | 229 |
| Apoptosis-related proteins | ||
| Bim/BOD (Bcl-2 interacting mediator of cell death/Bcl-2 related ovarian death gene) | I | 121 |
| DNA fragmentation factor 45 (DFF45) | D | 230 |
| p21 | I | 121 |
| Procaspase-3 | D | 230 |
| Procaspase-8 | D | 230 |
| Procaspase-9 | D | 230 |
| Receptor interacting protein (RIP)-like interacting CLARP kinase (RICK) | I | 230 |
| Zipper interacting protein kinase | I | 121 |
| Structural proteins | ||
| Collagen I, alpha-1, polypeptide | Enriched in amyloid plaques | 99 |
| Coronin, actin binding protein | Enriched in amyloid plaques | 99 |
| Drebrin | D | 231 |
| Fibrinogen, gamma | Enriched in amyloid plaques | 99 |
| NF-L | D | 232 |
| Tau | Enriched in amyloid plaques | 99 |
| Vimentin | Enriched in amyloid plaques | 99 |
| Proteolysis | ||
| Antitrypsin | Enriched in amyloid plaques | 99 |
| ATPase, Ca++ transporting plasma membrane protein 2 | Enriched in amyloid plaques | 99 |
| ATPase, H+ transporting, lysosomal V0 subunit A | Enriched in amyloid plaques | 99 |
| ATPase, H+ transporting, lysosomal V1 subunit B | Enriched in amyloid plaques | 99 |
| ATPase, H+ transporting, lysosomal V1 subunit D | Enriched in amyloid plaques | 99 |
| ATPase, H+ transporting, lysosomal V1 subunit E | Enriched in amyloid plaques | 99 |
| Cathepsin D | Enriched in amyloid plaques | 99 |
| Cystatin B | Enriched in amyloid plaques | 99 |
| Cystatin C | Enriched in amyloid plaques | 99 |
| Ubiquitin-activating enzyme E1 | Enriched in amyloid plaques | 99 |
| Vacuolar ATPase subunit H | Enriched in amyloid plaques | 99 |
| Glial associated proteins | ||
| Glial fibrillary acidic protein (GFAP) | I | 100 |
| Membrane trafficking proteins | ||
| Dynamin 1 | Enriched in amyloid plaques | 99 |
| Dynein, heavy polypeptide 1 | Enriched in amyloid plaques | 99 |
| Other | ||
| Amyloid beta-peptide | Enriched in amyloid plaques | 99 |
| CSF proteins | ||
| Alpha-1 antitrypsin | I | 233 |
| Alpha-1 beta glycoprotein | D | 233 |
| Apolipoprotein A1 | D | 233 |
| Apolipoprotein E | D | 233 |
| Apolipoprotein J | D | 233 |
| Beta-2 microglobulin | I | 234 |
| Cell cycle progression 8 protein | D | 233 |
| Kininogen | D | 233 |
| Proapolipoprotein | D | 234 |
| Retinol-binding protein | D | 233 |
| Transthyretin | I | 234 |