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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Exp Neurol. 2007 Jul 17;209(2):302–312. doi: 10.1016/j.expneurol.2007.07.005

Figure 1.

Figure 1

The prototypical myelin-derived neurite growth inhibitors, their receptors and intracellular signaling pathway. Oligodendrocyte-expressed Nogo, MAG, and OMgp all bind to GPI-anchored protein NgR1, which recruits co-receptor p75 or TROY and LINGO-1 to form a receptor complex to transduce the inhibitory signals in neurons. MAG also binds to NgR2, where the identity of co-receptors has not been confirmed. In neurons, the NgR1 receptor complex stimulates the dissociation of Rho-GDP from GDI and the subsequent formation of active Rho-GTP, which with additional downstream effectors leads to rearrangement of cytoskeletons to inhibit neurite outgrowth. Other downstream effectors for axon growth inhibition include PKC and EGFR, which are related to calcium influx. However, cAMP/PKA plays an opposite role by relieving the growth inhibition.