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. 2008 Feb 13;9(Suppl 1):S14. doi: 10.1186/1471-2105-9-S1-S14

Figure 1.

Figure 1

(A) Distribution of raw Profiles-3D (○) and lipid-corrected (●) compatibility scores (REPIMPS result) of 493 GPCR models. (B) Distribution of the improvement of the compatibility scores for the modelled GPCRs as a result of simulation of the presence of the hydrophobic lipid bilayer environment. Left y-axis represents the number of models, shown by bars, at each level of improvement and the right y-axis is the percentage of the cumulative distribution represented by the curve. (C) Average (± SD) of compatibility scores in the presence and absence of a lipid environment calculated by REPIMPS and Profiles-3D, respectively, for Helices I to VII of 493 models of GPCRs. Differences between compatibility scores calculated by REPIMPS and Profiles-3D methods are significant for all helices (p < 0.001).