Figure 2.

Effect of α-actinin-1 reduction on pressure-mediated CT26 tumor cell wound implantation. The 15 mm Hg-increased pressure (closed bars) stimulates the adhesion of siNT-transfected, ⁵¹Cr-labeled CT26 cells to murine surgical wounds compared with cells kept under ambient pressure conditions (open bars). Pressure failed to increase wound implantation of CT26 cells transfected with siACTN1 (*P < .01; n = 5). Adhesion was determined by the acquired radioactive counts per minute (cpm) of surgical wounds after a 30-minute exposure to ⁵¹Cr-labeled CT26 cells. Data were analyzed by paired Student's t test and graphically expressed as mean ± SEM.