Table 2.

Storage Stability of P12-Loaded Trastuzumab-Modified Nanoparticles.

Parameter		Week 0	Week 1	Week 2	Week 3	Week 4	Week 5	Week 6
Diameter	(nm)	263.8 ± 0.3	260.7 ± 3.8	259.6 ± 4.3	258.6 ± 3.5	265.7 ± 1.4	263.7 ± 3.5	266.6 ± 3.8
Polydispersity		0.092 ± 0.091	0.030 ± 0.030	0.025 ± 0.020	0.027 ± 0.025	0.022 ± 0.012	0.020 ± 0.012	0.067 ± 0.071
Zeta potential	(mV)	-43.1 ± 5.2	-32.0 ± 2.9	-36.9 ± 5.9	-31.5 ± 7.6	-37.9 ± 6.5	-36.1 ± 0.4	-36.5 ± 2.7
Trastuzumab	(%)	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
HSA	(%)	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
P12	(%)	3.5 ± 1.0	2.5 ± 0.4	3.2 ± 1.2	4.6 ± 1.2	5.3 ± 1.1	5.6 ± 1.5	6.3 ± 1.5

Physico-chemical properties were measured every week. The particle suspension was centrifuged and trastuzumab. HSA and P12 were determined in the supernatants. The time point Week 0 describes the loss during preparation (n = 3).

Values are presented as mean ± SD.