Figure 1.

Sequences of target mRNAs. (A) 5′ proximal sequence of the plus strand of the PB2 gene of the influenza strain A/PR/8/34 (see ref. 45). The start codon is enlarged and in bold type. The sites in the gene that were chosen for targeting by EGSs are underlined. The first underlined nucleotide at each site is a guanosine that was shown to be accessible to cleavage by RNase T1. The sites were chosen to have a uracil residue in position 8 after the guanosine. (B) 5′ proximal sequence of the plus strand of the NP gene of the influenza strain A/PR/8/34 (see ref. 46).