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. 2008 Mar 3;118(4):1563–1570. doi: 10.1172/JCI32796

Figure 2. Effects of agonist treatment on ABR thresholds 24 h after acoustic trauma.

Figure 2

ABR threshold shifts 24 h after acoustic trauma in female WT and ARKO mice pretreated with either the ERα agonist (PPT), or the ERβ agonist (DPN). Control WT and ARKO mice were pretreated with saline. PPT treatment showed only partial protection at 12.5 and 16 kHz in ARKO mice. The amount of threshold shift was less for the DPN-treated mice compared with the vehicle-treated mice at 12.5 kHz in WT and at all frequencies in ARKO mice. All data are mean ± SEM, n = 3 in each group. *P < 0.05; **P < 0.01; ***P < 0.001 by 2-way ANOVA.