Figure 3.

Model of AIRE–PHD1 in complex with H3K4me0. (A) Surface representation of AIRE–PHD1 in complex with H3K4me0. Residues with the highest chemical shifts are shown in magenta (Δδ>0.4 p.p.m.) and pink (0.2<Δδ<0.4 p.p.m.). (B) Ribbon representation of a representative structure of the complex of AIRE1–PHD1 (blue) with H3K4me0 (orange). Inter-backbone hydrogen bonds and Zn²⁺ ions are represented by dotted lines and spheres, respectively. AIRE, autoimmune regulator; H3K4me0, histone H3 non-methylated at lysine 4; PHD, plant homeodomain.