Table 3.
Examples of mouse models for the NER pathway
| Genotype | Developmental defects | Fertility defects | Induced tumorigenesis | References |
|---|---|---|---|---|
| Xpd−/− | Pre-implantation embryonic lethality | NA | NA | (de Boer et al, 1998b) |
| XpdR722W/R722W | Growth retardation | None | UV- and DMBA-induced skin cancer | (de Boer et al, 1998a, 1999) |
| XpdG602D/G602D | Growth retardation | None | Early onset of UV-induced skin and/or eye tumours | (Andressoo et al, 2006) |
| Xpe−/− | None | None | UV-induced skin cancer | (Itoh et al, 2004; Yoon et al, 2005) |
| Xpa−/− | None | None | UV- and DMBA-induced skin cancer | (Nakane et al, 1995) |
| Xpc−/− | None | None | UV-induced skin cancer | (Sands et al, 1995) |
| Xpg−/− | Growth retardation and premature death | NA | NA | (Harada et al, 1999) |
| Ddb1−/− | Early embryonic lethality | NA | NA | (Cang et al, 2006) |
| HR23A−/− | Unaffected | None | NT | (Ng et al, 2002) |
| HR23B−/− | Intrauterine/neonatal death. 10% viable but growth retarded | Male infertility | NT | (Ng et al, 2002) |
| HR23A−/−; HR23B−/− | Embryonic lethality | NA | NA | (Ng et al, 2003) |
| Csa−/− | None | None | UV-induced skin cancer | (van der Horst et al, 1997) |
| Csb−/− | None | None | UV-induced skin cancer | (van der Horst et al, 2002) |
| Ercc1−/− | Growth retardation and death before weaning | NA | NA | (McWhir et al, 1993; Weeda et al, 1997) |
| Xpf−/− | Growth retardation and death before weaning | NA | NA | (Tian et al, 2004b) |
| NA, not applicable; NT, not tested. | ||||