Table 1.
Up-regulated genes in IPAH vs. controls: at least 1.3 fold up-regulated in GCOS and GSS
| Gene Name | Fold Change | Description | Gene Symbol | GO Biological Process Description |
| 205033_s_at | 30.76 | defensin, alpha 1, myeloid-related sequence | DEFA1 /// DEFA3 | xenobiotic metabolism /// response to virus /// defense response to bacteria /// defense response to fungi /// defense response /// response to pest, pathogen or parasite |
| 204351_at | 15.05 | S100 calcium binding protein P | S100P | endothelial cell migration |
| 232629_at | 10.03 | prokineticin 2 | PROK2 | activation of MAPK activity /// angiogenesis /// anti-apoptosis /// chemotaxis /// inflammatory response /// elevation of cytosolic calcium ion concentration /// neuropeptide signaling pathway /// spermatogenesis /// cell proliferation /// sensory percept |
| 202917_s_at | 5.678 | S100 calcium binding protein A8 (calgranulin A) | S100A8 | inflammatory response |
| 211654_x_at | 5.479 | major histocompatibility complex, class II, DQ beta 1 | HLA-DQB1 | immune response /// immune response /// antigen presentation, exogenous antigen /// antigen processing, exogenous antigen via MHC class II |
| 209773_s_at | 5.435 | ribonucleotide reductase M2 polypeptide | RRM2 | DNA replication /// deoxyribonucleoside diphosphate metabolism /// DNA replication |
| 220005_at | 5.189 | G protein-coupled receptor 86 | P2RY13 | signal transduction /// G-protein coupled receptor protein signaling pathway |
| 225987_at | 4.787 | likely ortholog of mouse tumor necrosis-alpha-induced adipose-related protein | STEAP4 | fat cell differentiation /// electron transport |
| 209773_s_at | 5.435 | ribonucleotide reductase M2 polypeptide | RRM2 | DNA replication /// deoxyribonucleoside diphosphate metabolism /// DNA replication |
| 220005_at | 5.189 | G protein-coupled receptor 86 | P2RY13 | signal transduction /// G-protein coupled receptor protein signaling pathway |
| 225987_at | 4.787 | likely ortholog of mouse tumor necrosis-alpha-induced adipose-related protein | STEAP4 | fat cell differentiation /// electron transport |
| 212999_x_at | 4.322 | major histocompatibility complex, class II, DQ beta 1 | HLA-DQB1 | immune response /// immune response /// antigen presentation, exogenous antigen /// antigen processing, exogenous antigen via MHC class II |
| 220167_s_at | 3.448 | TP53TG3 protein | TP53TG3 | --- |
| 223204_at | 3.429 | hypothetical protein DKFZp434L142 | DKFZp434L142 | --- |
| 213975_s_at | 2.807 | lysozyme (renal amyloidosis) | LYZ /// LILRB1 | carbohydrate metabolism /// cell wall catabolism /// cytolysis /// defense response to bacteria /// immune response /// response to virus /// tRNA aminoacylation for protein translation |
| 209514_s_at | 2.779 | RAB27A, member RAS oncogene family | RAB27A | intracellular protein transport /// small GTPase mediated signal transduction /// protein transport |
| 228898_s_at | 2.13 | similar to putative NADH oxidoreductase complex I subunit homolog. | SMARCB1 | chromatin remodeling /// transcription /// regulation of transcription from RNA polymerase II promoter /// cell cycle /// DNA integration /// negative regulation of progression through cell cycle /// retroviral genome replication /// regulation of transcription |
| 201310_s_at | 2.039 | chromosome 5 open reading frame 13 | C5orf13 | --- |
| 227724_at | 1.956 | hypothetical gene supported by AK091744 | LOC439987 | --- |
| 208704_x_at | 1.92 | amyloid beta (A4) precursor-like protein 2 | APLP2 | G-protein coupled receptor protein signaling pathway |
| 222688_at | 1.916 | yf40c04.s1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE:129318 3', mRNA sequence. | PHCA | protein biosynthesis /// ceramide metabolism |
| 214864_s_at | 1.852 | glyoxylate reductase/hydroxypyruvate reductase | GRHPR | L-serine biosynthesis /// excretion /// metabolism /// metabolism |
| 230126_s_at | 1.774 | KIAA0876 protein | JMJD2B | regulation of transcription, DNA-dependent |
| 207426_s_at | 1.774 | tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa) | TNFSF4 | immune response /// signal transduction /// cell-cell signaling /// positive regulation of cell proliferation |
| 212998_x_at | 1.759 | major histocompatibility complex, class II, DQ beta 2 | HLA-DQB2 | immune response /// immune response /// antigen presentation, exogenous antigen /// antigen processing, exogenous antigen via MHC class II |
| 212495_at | 1.745 | KIAA0876 protein | JMJD2B | regulation of transcription, DNA-dependent |
| 221581_s_at | 1.676 | Williams-Beuren syndrome chromosome region 5 | LAT2 | intracellular signaling cascade /// calcium-mediated signaling /// immune response /// mast cell degranulation /// B cell activation |
| 208248_x_at | 1.672 | amyloid beta (A4) precursor-like protein 2 | APLP2 | G-protein coupled receptor protein signaling pathway |
| 226456_at | 1.66 | hypothetical protein MGC24665 | MGC24665 | --- |
| 208703_s_at | 1.651 | amyloid beta (A4) precursor-like protein 2 | APLP2 | G-protein coupled receptor protein signaling pathway |
| 212496_s_at | 1.625 | KIAA0876 protein | JMJD2B | regulation of transcription, DNA-dependent |
| 223445_at | 1.588 | dystrobrevin binding protein 1 | DTNBP1 | organelle organization and biogenesis /// sensory perception /// visual perception /// response to stimulus |
| 225593_at | 1.578 | U7 snRNP-specific Sm-like protein LSM10 | LSM10 | nuclear mRNA splicing, via spliceosome /// mRNA processing |
| 223361_at | 1.537 | similar to HSPC280 | C6orf115 | --- |
| 224948_at | 1.477 | mitochondrial ribosomal protein S24 | MRPS24 | --- |