Table 4.

[en] Adjusted hazard ratios (HRs), p values (p), and 95% confidence interval (95%CI) for overall survival as a function of comorbidity severity (HRs were controlled for stage, grade, age, race, and gender)

Comorbidity	Entire cohort	Subset with noninvasive disease	Subset treated with cystectomy
None	Reference	Reference	Reference
Mild	HR, 1.17 p = 0.3175 95%CI, 0.86[en]1.60	HR, 1.15 p = 0.6135 95%CI, 0.70[en]1.89	HR, 1.27 p = 0.3858 95%CI, 0.75[en]2.15
Moderate	HR, 1.69 p = 0.0013 95%CI, 1.22[en]2.33	HR, 1.89 p = 0.0093 95%CI, 1.16[en]3.07	HR, 1.42 p = 0.2669 95%CI, 0.78[en]2.59
Severe	HR, 2.54 p = 0.0001 95%CI, 1.78[en]3.63	HR, 3.68 p = 0.0001 95%CI, 2.19[en]6.19	HR, 2.65 p = 0.0047 95%CI, 1.33[en]5.28