Table 1.
Human brain tissue used in this study
| Case | Age at death (years) | Gender | PMI (h) | Braak stagea | Tangle scoreb |
|---|---|---|---|---|---|
| AD 1 | 89 | F | 3 | V | 14.5 |
| AD 2 | 80 | F | 2.25 | VI | 14.5 |
| AD 3 | 78 | F | 1.83 | VI | 15.0 |
| AD 4 | 95 | F | 3.16 | VI | 10.0 |
| AD 5 | 86 | M | 2.25 | VI | 13.5 |
| AD 6 | 91 | F | 3 | V | 8.50 |
| Mean ± SD | 86.5 ± 6.5 | 2.58 ± 0.54 | 12.67 ± 2.73 | ||
| Con 1 | 85 | M | 25 | II | 4.25 |
| Con 2 | 86 | F | 2.5 | III | 5.00 |
| Con 3 | 81 | M | 2.75 | III | 6.41 |
| Con 4 | 88 | F | 3 | II | 2.00 |
| Con 5 | 90 | F | 3 | III | 4.50 |
| Con 6 | 88 | F | 3.5 | III | 2.50 |
| Con 7 | 88 | F | 3 | IV | 4.50 |
| Mean ± SD | 86.6 ± 2.9 | 2.89 ± 0.39 | 4.17 ± 1.50 |
PMI, postmortem interval; AD, Alzheimer disease.
a
Neurofibrillary pathology was staged according to Braak and Braak (1995).
b
Tangle score was a density estimate and was designated as none, sparse, moderate, or frequent (0, 1, 2, or 3 for statistics), as defined according to CERAD AD criteria (Mirra et al. 1991). Five areas (frontal, temporal, parietal, hippocampal, and entorhinal) were examined, and the scores were added up for a maximum of 15.