Table 1. Frequency of putative NRTI- and AZT-related mutations found among viruses from patients with NRTI or with AZT monotherapy exposure.
| Mutation | Frequency Naïve | Frequency NRTI-treated | p-value | Frequency AZT-treated | p-value |
| I326V | 17.2% (15/87) | 6.4% (12/188) | 0.008 | 7.1% (02/28) | 0.157 |
| R358K | 9.2% (08/87) | 18.7% (35/187) | 0.049 | 14.3% (04/28) | 0.326 |
| G359S | 3.4% (03/87) | 15% (28/187) | 0.004 | 10.7% (03/28) | 0.154 |
| A360T | 9.2% (08/87) | 17.6% (33/187) | 0.028 | 14.3% (04/28) | 0.326 |
| A360V | 0% (00/87) | 9.1% (17/187) | 0.002 | 14.3% (04/28) | 0.003 |
| K366R | 4.6% (04/87) | 16.7% (31/186) | 0.006 | 10.7% (03/28) | 0.225 |
| A371V | 2.3% (02/87) | 22.6% (42/186) | <0.001 | 17.9% (05/28) | 0.009 |
| K390R | 27.6% (24/87) | 40.9% (76/186) | 0.043 | 60.7% (17/28) | 0.002 |
| A400T | 43.2% (32/74) | 69% (119/172) | <0.001 | 71.4% (20/28) | 0.001 |
| T470N | 6.5% (06/93) | 0.6% (01/177) | 0.007 | 3.7% (01/27) | 0.841 |
| I506L | 0% (00/93) | 6.9% (04/58) | 0.020 | NA** | NA |
| K512R | 8.6% (08/93) | 0% (00/58) | 0.024 | NA | NA |
| K527N | 1.1% (01/93) | 17.2% (10/58) | <0.001 | NA | NA |
| K530R | 1.1% (01/93) | 12.1% (07/58) | 0.010 | NA | NA |
| Q547K | 0% (00/93) | 6.9% (04/58) | 0.020 | NA | NA |
*
Significant p-values at the 0.05 level are boldfaced
**
NA, data not available