Table 1. Childhood obesity case-control association study results for FTO region markers perfectly correlated with rs9939609 in Caucasians (bold) plus all other markers present on the BeadChip in the corresponding HapMap CEU region of LD in our (a) Caucasian and (b) African American cohorts respectively.
(a) Caucasians | ||||||||||
Chr | SNP | r2 to rs9939609 | B35 location | Minor Allele | Major Allele | Aff MAF (n = 418) | Ctrl MAF (n = 2270) | OR | 95% CI | P-value |
16 | rs9930333 | 0.843 | 52357478 | T | G | 0.476 | 0.425 | 1.228 | 1.058–1.427 | 0.0070 |
16 | rs10852521 | 0.584 | 52362466 | T | C | 0.422 | 0.484 | 0.779 | 0.670–0.906 | 0.0011 |
16 | rs16945088 | 0.099 | 52370025 | G | A | 0.094 | 0.090 | 1.056 | 0.818–1.365 | 0.68 |
16 | rs8050136 | 1 | 52373776 | A | C | 0.448 | 0.391 | 1.266 | 1.088–1.471 | 0.0022 |
16 | rs3751812 | 1 | 52375961 | T | G | 0.443 | 0.386 | 1.267 | 1.089–1.473 | 0.0022 |
16 | rs12597786 | 0.014 | 52378808 | T | C | 0.026 | 0.020 | 1.320 | 0.815–2.138 | 0.26 |
16 | rs9931164 | 0.022 | 52382739 | G | A | 0.020 | 0.019 | 1.024 | 0.597–1.756 | 0.93 |
16 | rs9941349 | 0.9 | 52382989 | T | C | 0.462 | 0.407 | 1.254 | 1.080–1.457 | 0.0030 |
16 | rs7199182 | - | 52383621 | G | A | - | - | - | - | - |
16 | rs7190492 | 0.328 | 52386253 | A | G | 0.296 | 0.354 | 0.767 | 0.651–0.903 | 0.0014 |
16 | rs8044769 | 0.62 | 52396636 | T | C | 0.414 | 0.483 | 0.758 | 0.652–0.881 | 0.00031 |
16 | rs6499646 | 0.101 | 52401034 | C | T | 0.103 | 0.092 | 1.141 | 0.890–1.462 | 0.30 |
16 | rs1421090 | 0.026 | 52407671 | C | T | 0.273 | 0.260 | 1.073 | 0.907–1.270 | 0.41 |
Minor allele frequencies (MAF), allelic test P-values, and odds ratios (OR) with 95% confidence intervals (CI) are shown for each SNP. rs7199182 has a MAF<1% in Caucasians so was not analyzed in that ethnicity. The ORs shown are for the minor allele. P-values are two-sided in each instance. r2 values to rs9939609 derived from (a) CEU and (b) YRI HapMap samples are also shown.