Scheme 3.
(a) LiOH, THF/H2O (b) EDC, HOBt, 2,6-lutidine, DMF (c) 1,4-cyclohexadiene, 20% Pd(OH)2/C, THF/EtOH, Δ, 2d (d) HATU, NMM, DMF (e) TFA, CH2Cl2 (f) Ac2O, pyridine (g) MeOH, HCl, HCHO/H2O; NaBH4.
(a) LiOH, THF/H2O (b) EDC, HOBt, 2,6-lutidine, DMF (c) 1,4-cyclohexadiene, 20% Pd(OH)2/C, THF/EtOH, Δ, 2d (d) HATU, NMM, DMF (e) TFA, CH2Cl2 (f) Ac2O, pyridine (g) MeOH, HCl, HCHO/H2O; NaBH4.