Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic Representation of Potential PELP1/MNAR Autocrine Signaling Loop in Breast Cancer Cells
Growth factor signaling and/or activation of nongenomic signaling pathways promote ER coactivator PELP1 to form a complex with ERRα and PNRC2, leading to activation of aromatase expression promoting formation of a positive feedback loop locally synthesizing E2, resulting in the activation of E2-ER-PELP1 signaling in breast cancer cells.
