Table 2.
Hormone Concentrations
| ALLO |
Progesterone |
Estradiol |
Corticosterone |
|||||
|---|---|---|---|---|---|---|---|---|
| Line | Treatment | mg/kg | ng/mL | n | pg/mL | n | μg/dL | n |
| WSP-1 | Air | 0 | 1.0 ± 0.6 | 2 | 22.1 ± 2.6 | 5 | 38.9 ± 7.2 | 3 |
| 3.2 | 0.4 ± 0.2 | 3 | 25.9 ± 8.4 | 5 | 24.0 ± 8.4 | 4 | ||
| 10 | 1.0 ± 0.3 | 3 | 17.7 ± 4.9 | 7 | 29.1 ± 7.4 | 7 | ||
| 17 | 1.9 ± 0.4 | 4 | 15.3 ± 2.4 | 6 | 21.0 ± 7.2 | 5 | ||
| Ethanol | 0 | 0.7 ± 0.2 | 7 | 21.9 ± 3.9 | 8 | 69.0 ± 5.7 | 7 | |
| 3.2 | 0.7 ± 0.2 | 6 | 21.5 ± 4.4 | 8 | 59.2 ± 10.9 | 6 | ||
| 10 | 1.7 ± 0.3 | 8 | 25.9 ± 4.0 | 9 | 54.9 ± 5.7 | 9 | ||
| 17 | 1.8 ± 0.2 | 13 | 19.0 ± 2.8 | 12 | 43.5 ± 9.6 | 12 | ||
| WSR-1 | Air | 0 | 2.6 ± 1.8 | 4 | 34.6 ± 8.9 | 5 | 41.7 ± 6.4 | 6 |
| 3.2 | 4.0 ± 1.7 | 3 | 30.5 ± 8.7 | 8 | 40.2 ± 10.1 | 7 | ||
| 10 | 3.8 ± 0.4 | 2 | 12.1 ± 6.6 | 3 | 42.2 ± 9.6 | 4 | ||
| 17 | 5.4 ± 2.3 | 3 | 27.0 ± 8.9 | 7 | 39.6 ± 10.7 | 8 | ||
| Ethanol | 0 | 1.2 ± 0.2 | 6 | 30.8 ± 3.7 | 7 | 86.9 ± 11.0 | 6 | |
| 3.2 | 1.5 ± 0.1 | 6 | 40.0 ± 10.7 | 7 | 35.5 ± 10.1 | 7 | ||
| 10 | 2.3 ± 0.3 | 7 | 46.5 ± 10.2 | 8 | 50.9 ± 11.8 | 7 | ||
| 17 | 5.9 ± 1.1 | 5 | 57.9 ± 14.2 | 6 | 75.4 ± 15.3 | 4 | ||
Plasma was collected from all animals immediately following the terminal convulsion endpoint, and hormone levels were measured by radioimmunoassay (RIA). Values are the mean ± SEM for the number of animals listed. Due to the amount of plasma required for both the estradiol and progesterone RIAs, we were unable to obtain estradiol and progesterone levels for a small number of animals.