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. Author manuscript; available in PMC: 2008 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2006 Oct 4;17(8):2380–2384. doi: 10.1016/j.bmcl.2006.09.093

Table 1.

Cell growth inhibition by 5-aza-ellipticine derivatives

Compound IC50 (μM) on HCT116 cells IC50 (μM) on 3T3 cells
Ellipticine (1) 0.3 0.003
(2) 0.07 0.02
7 >1 >1
8 0.3 0.6
9 N/A 1
11 2 N/A
12 >10 N/A
13 0.2 N/A
14 0.4 N/A
15 3 N/A
16 0.3 N/A

N/A, not tested.