Table 2.

Isotopic distribution in carbons of glucose produced from [2-¹³C]pyruvate substrate by perfused liver from ob/ob and lean mice

Relative 13C enrichment of glucose	ob/ob liver (20)*	Lean liver (5)†
C-1	73.6  ±  1.4	78.5  ±  0.6
C-2	89.7  ±  1.5	96.0  ±  0.6
C-3	34.6  ±  1.3	48.0  ±  3.0
C-4	38.4  ±  1.3	51.0  ±  3.0
C-5	100.0	100.0
C-6	79.0  ±  1.0	81.0  ±  3.0
	0.91  ±  0.01	0.96  ±  0.02

Although distributions for the individual livers were used in calculations, mean values are given to indicate the liver-to-liver variation in this distribution. 

^*Mean values for 20 ob/ob livers of which eight were untreated controls, five were treated with leptin in vitro only, and seven were perfused in absence of hormone but were from mice treated with leptin in vivo. Leptin treatment as given in Table 1. 

^†Mean values for two untreated lean mouse livers and three lean livers treated with leptin in vitro.