Skip to main content
. 1998 Jun 9;95(12):6768–6773. doi: 10.1073/pnas.95.12.6768

Figure 5.

Figure 5

Stereo view of the details of the structure of 2,5-DKGR A and aldose reductase in the vicinity of the NADPH cofactor binding site. In aldose reductase (green), the loop 7 region completely covers the NADPH cofactor (cyan) by means of electrostatic interactions between residues Lys-21, Asp-216, and Lys-262. In 2,5-DKGR A (magenta), however, this loop is shorter and does not clamp over the cofactor. In aldose reductase a major rearrangement of the loop 7 region appears necessary to allow the NADPH cofactor to enter and exit the binding cleft.