Effects of tissue-specific age-1 expression on lifespan and FIRE response. Adult lifespan and FIRE response were plotted to examine the correlation between these phenotypes. In all panels, black diamond, wildtype; white diamonds are age-1(lf) alleles, as indicated in (A); grey diamond, daf-16(mg242); age-1(mg109). For age-1(mg44) and age-1(mg109), fertile adults were age-1(mg44/mg44) progency of age-1(mg44/+) hermaphrodites. Crosses, circles and triangle shapes represent tissue-specific age-1 or daf-16 expression, as indicated.