Table 6.

Adult lifespan of animals with tissue-restricted transgenic expression of gfp:daf-16

Genotype	Mean (days)	Std error	(n)	Expt.	% Increase	P vs control a
daf-16(+);age-1(+)	15.3	0.74	38	1	31
daf-16(+);age-1(+)	19.2	0.48	85	2	41
daf-16(+);age-1(+)	16.8	0.30	49	3	29
daf-16(+);age-1(+)	19.7	1.12	36	4b	25
age-1(mg109) m+z−	22.2	0.51	33	3	46
age-1(mg109) m+z−	35.5	1.86	23	4b	59
daf-16(mg242); age-1(mg109)	10.6	0.31	42	1
daf-16(mg242); age-1(mg109)	11.3	0.67	21	2
daf-16(mg242); age-1(mg109)	11.9	0.18	42	3
daf-16(mg242); age-1(mg109)	14.7	0.19	61	4b
Ubiquitous daf-16 (Pdpy-30:daf-16)
daf-16(−);age-1(−); bvEx130	15.7	0.59	25	3	25	<0.0001, <0.0001
daf-16(−);age-1(−); bvEx130	19.5	0.90	29	4b	25	<0.0001, <0.0001
Neuronal daf-16 (Pric-19:daf-16)
daf-16(−);age-1(−); bvEx94	13.0	0.41	46	1	18	<0.0001, <0.0001
daf-16(−);age-1(−); bvEx94	12.8	0.41	33	3	7	0.0023, 0.0037
daf-16(−);age-1(−); bvEx94	16.0	0.71	28	4b	8	0.0043, 0.0883
daf-16(−);age-1(−); bvEx92	11.1	0.32	35	1	5	0.2902, 0.2660
daf-16(−);age-1(−); bvEx93	12.8	0.36	46	1	17	<0.0001, <0.0001
daf-16(−);age-1(−); bvEx96	11.3	0.48	40	1	6	0.0578, 0.2336
daf-16(−);age-1(−); bvEx98	11.8	0.50	24	1	10	0.0744, 0.0499
Intestinal daf-16 (Pgly-19:daf-16, Pspl-1:daf-16)
daf-16(+); bvEx103	18.5	0.36	76	2	−4	0.0160, 0.0256
daf-16(+); bvEx105	19.3	0.43	79	2	0	0.6309, 0.5742
daf-16(−);age-1(−); bvEx#13	11.9	0.88	7	1	11	0.1244, 0.2050
daf-16(−);age-1(−); bvEx#P1	12.3	0.65	19	1	14	0.0278, 0.0300
Neuronal + intestinal daf-16(Pric-19: daf-16 + Pgly-19:daf-16)
daf-16(−);age-1(−); bvEx113	14.5	0.45	62	2	22	<0.0001, <0.0001
daf-16(−);age-1(−); bvEx113	14.6	0.46	39	3	18	<0.0001, <0.0001
daf-16(−);age-1(−); bvEx113	18.0	0.61	53	4b	18	<0.0001, <0.0001
daf-16(−);age-1(−); bvEx114	14.9	0.61	31	2	24	<0.0001, <0.0001
daf-16(−);age-1(−); bvEx114	14.1	0.48	40	3	16	<0.0001, <0.0001
daf-16(−);age-1(−); bvEx114	19.3	0.98	28	4b	24	<0.0001, <0.0001

^aLog-Rank, Wilcoxan, versus non-transgenic control.

^bExperiment 4 was performed at 20°C; Expts. 1–3 were performed at 25°C.