FIGURE 4.

Inflammatory responses to airway administration of LPS in gonadectomized and sham-operated C57BL/6 mice. A, Castration of male mice resulted in a reduced hypothermic response following LPS administration relative to sham-operated male mice, whereas ovariectomized female mice did not exhibit an altered response relative to sham-operated females. B and C, Castrated male mice exhibited decreased BAL fluid cells (B) and TNF-α content (C) in response to LPS administration relative to sham-operated male mice, whereas ovariectomized female mice did not exhibit altered responses relative to sham-operated females. *, p < 0.05 vs sham-operated females. ^, p < 0.05 vs sham-operated males. n = 8–9 per group.