FIGURE 5.

Inflammatory responses to airway administration of LPS in intact male C57BL/6 mice treated with flutamide and in intact female C57BL/6 mice treated with DHT. A, Treatment of male mice with flutamide did not alter the hypothermic response relative to placebo-treated male mice. In contrast, female mice treated with DHT exhibited a more severe hypothermia following LPS administration relative to placebo-treated female mice. B and C, BAL fluid cells (B) and TNF-α content (C) were not altered in flutamide-treated male mice relative to placebo-treated male mice in response to LPS, whereas DHT-treated female mice exhibited increases in both parameters relative to placebo-treated female mice in response to LPS. *, p < 0.05 vs placebo-treated females. ^, p < 0.05 vs placebo-treated males. n = 8–14 per group.