FIGURE 6.
Analysis of respiratory mechanics and airway responsiveness in mechanically ventilated C57BL/6 mice following administration of LPS. A, Total respiratory system resistance, determined by the single-compartment model of respiratory mechanics, demonstrated increased responsiveness to aerosolized methacholine in males and DHT-treated females in comparison to females and castrated males. B, Provocative concentrations for R, E, Rn, G, and H demonstrated that males were more sensitive than females to aerosolized methacholine. Castration reduced the sensitivity of males (increased PC values), whereas DHT administration increased the sensitivity of females (decreased PC values). *, p < 0.05 vs females. ^, p < 0.05 vs males, n = 7–8 per group.