FIGURE 7.
Gender differences in airway responsiveness and LPS-induced airway inflammation in BALB/c mice. A, Calculated provocative concentrations of methacholine aerosol for resistance (R), elastance (E), Newtonian resistance (Rn), tissue damping (G), and tissue elastance (H) were lower in naive males than in females, indicative of increased sensitivity to methacholine. *, p < 0.05 vs females. n = 9 per group. B and C, BAL fluid cells (B) and TNF-α content (C) were increased in LPS-treated males compared with females. *, p < 0.05 vs LPS-treated females. ^, p < 0.05 vs saline-treated animals of the same gender. n = 9–22 per group.