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. Author manuscript; available in PMC: 2008 Jun 5.
Published in final edited form as: Virology. 2007 Feb 9;362(2):441–452. doi: 10.1016/j.virol.2007.01.001

Figure 3. B5-VRP induces long-lasting, high levels of anti-B5 serum IgG.

Figure 3

A. Six week-old BALB/c mice were primed with 1 × 106 IU B5-VRP subcutaneously in the rear foot-pad at time 0. Mice were boosted with the same dose at 4 and 42 weeks post-prime. Sera were collected at various time points up to 50 weeks post-prime and were used for B5 ELISA. Serum IgG ELISA titers are reported as the geometric mean of the reciprocal dilution at which the sample absorbance was greater than 0.2 at 450 nm. B. Six week-old BALB/c mice were primed with 1 × 106 IU B5-VRP, 10 µg purified B5, or PBS subcutaneously in the rear foot-pads. Four weeks post-prime, mice were boosted with the same dose of VRP, protein, or PBS. Sera were collected two weeks post-boost and was assayed for B5 serum IgG titers by ELISA.