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. Author manuscript; available in PMC: 2008 Jun 5.
Published in final edited form as: Virology. 2007 Feb 9;362(2):441–452. doi: 10.1016/j.virol.2007.01.001

Figure 7. Mice vaccinated with VRP are protected from intranasal challenge with cowpox virus (Brighton red).

Figure 7

Six-week old BALB/c mice were primed with 1 × 106 IU B5-VRP, A33-VRP, and A27-VRP, or a cocktail of all three VRP (3X Cocktail). Mice were also primed and boosted with 1 × 106 IU HA-VRP as an irrelevant vaccine control. Three weeks post-boost, mice were anesthetized with Ketamine / xylazine and challenged with 1 × 106 pfu cowpox virus Brighton red. A group of unvaccinated mice was also challenged with 5 µL diluent to serve as mock challenge controls. A. Mice were monitored daily for weight loss. Statistics shown are in comparison to HA-VRP vaccinated mice challenged with 1 × 106 pfu cowpox virus Brighton red. B. Challenged mice were monitored daily for clinical signs of illness. Values are defined in Figure 5. The number of surviving mice per group of 8 are noted with *.