Table 1.

Comparison of heat shock and celastrol-induced gene expression

Gene familya	Median induction ratiob
	Heat shock (1.0)	Celastrol (0.9)
Xenobiotic metabolism and clearance
Glutathione metabolic enzymes	2.2	5.7
ECM4, GLO1, GLO4, GLR1, GSH1, GTT2, YJL068C
Aryl-alcohol dehydrogenases	1.0	5.6
AAD3, AAD4, AAD6, AAD14, AAD15, AAD16
Other putative xenobiotic oxidoreductases	1.9	9.1
ADH5, ADH6, ALD4, ALD6, BDH2, FRE7, GRE2, GOR1, OYE2, OYE3, YDL124W, YGL157W, YHB1, YML131S, YNL134C, YPR1, ZTA1
Export pumps	1.4	5.8
ATR1, FLR1, PDR5, PDR10, PDR15, PDR16, SNQ2, YCF1, YOR1
Protein folding, processing, and turnover
Chaperones and co-chaperones	6.2	4.9
CPR1, CPR6, HSP26, HSP31, HSC82, HSP82, HSP104, PDI1, PHB1, PHB2, SBA1, SGT1, SSA1, SSA2, SSA4, SSE1
Protein reductants	1.2	3.7
AHP1, MXR1, TRX2
Regulators of protein turnover/proteasome subunits	2.0	3.1
BLM10, CDC48, DDI1, DSK2, ECM29, LAP4, NPL4, OUT1, PIM1, PRD1, PRE2, PRE3, PRE4, PRE5, PRE6, PRE7, PRE10, PUP1, PUP2, PUP3, RPN1, RPN2, RPN3, RPN5, RPN6, RPN7, RPN8, RPN9, RPN11, RPN12, RPN13, RPT1, RPT3, RPT5, RPT6, SCL1, SHP1, UBA1, UBC5, UBI4, UBP6, UBX5, UFD1, UMP1, YME1

^a Genes selected based on induction ratio ≥2.0.

^b Global induction medians shown for each treatment in parentheses.