Presence of vesicular accumulations in human PD LBs. EM micrographs of LBs from the substantia nigra of a PD patient. LBs were composed of a dense fibrillar core with associated small vesicular accumulations (arrow) around the perimeter (A–E). Examination of sites more distal to the LBs revealed less dense distribution of small vesicles than that seen around the LB perimeter (F). Scale bars, (A, C, and E) 2 μm. (B, D, and F) 500 nm.